Coluracetam

Product name:Coluracetam
Chemical name: N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide.
CAS:135463-81-9
Purity: 99%
Appearance: white crystalline powder
Package: 1kg/bag.

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Product Description

Description Coluracetam (BCI-540) is a nootropic drug of the racetam family.Coluracetam (formerly known as MKC-231) was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer’s disease. After the drug failed to reach endpoints in its clinical trials it was in-licensed by BrainCells Inc for investigations into major depression disorder (MDD), after being awarded a “Qualifying Therapeutic Discovery Program Grant” by the state of California.Findings from its Phase 2a clinical trials have suggested that it would be an ideal medication for co-morbid MDD with generalized anxiety disorder (GAD).BrainCells Inc is currently out-licensing the drug for this purpose.It may also have potential use in prevention and treatment of ischemic retinopathy and retinal and optic nerve injury.
Coluracetam enhances high-affinity choline uptake (HACU) which is the rate-limiting step of acetylcholine (ACh) synthesis, and is the only known choline uptake enhancer to currently exist. Studies have shown Coluracetam to improve learning impairment on a single oral dose given to rats which have been exposed to cholinergic neurotoxins. Subsequent studies have shown that it may induce long-lasting procognitive effects by changing the choline transporter regulation system.
Density 1.3±0.1 g/cm3
Boiling Point 634.1±55.0 °C at 760 mmHg
Molecular Formula C19H23N3O3
Molecular Weight 341.404
Flash Point 337.3±31.5 °C
Exact Mass 341.173950
PSA 75.44000
LogP 3.27
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.641

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